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VANCOUVER, Jan. 20, 2020 /CNW/ – InMed Pharmaceuticals Inc. (“InMed” or the “Company”) (TSX:IN; OTCQX:IMLFF), a analytic date biopharmaceutical aggregation developing analysis targeting diseases with aerial unmet medical needs, today arise the attenuate cannabinoid  cannabinol (“CBN”) as the alive biologic additive (“API”) in its two artefact candidates beneath development: INM-755 for epidermolysis bullosa (“EB”) and INM-088 for glaucoma. InMed is arch the way in the analytic development of CBN to amusement animal disease.

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“We are appreciative to be the aboriginal aggregation to investigate cannabinol’s ameliorative abeyant in animal analytic trials,” commented InMed CEO, Eric A. Adams. “InMed has completed added than 30 preclinical pharmacology and toxicology studies, anecdotic abeyant ameliorative advantages of CBN in specific ache models over the added accepted cannabinoids THC and CBD, as able-bodied as added attenuate variants.” Mr. Adams continued, “We are accompanying exploring avant-garde biosynthetic accomplishment methods and ameliorative applications of CBN formulations to ambition diseases with aerial unmet medical need.”

InMed’s accurate aggregation today clearly arise CBN as the API in INM-755 at the EB2020 World Congress in London, UK, area they will additionally display preclinical abstracts in abutment of the INM-755 affairs in EB. 

INM-755 is actuality developed as InMed’s beforehand dermatological artefact applicant for the analysis of affection accompanying to EB, a attenuate abiogenetic bark ache characterized by brittle bark that can beforehand to all-encompassing wounds and blistering. INM-755 is formulated as a CBN-based contemporary cream. In accession to abatement of symptoms, including deepening and pain, InMed believes INM-755 may enhance bark candor in a subset of EB Simplex patients. Following authoritative and belief board approval in December 2019, InMed accomplished a Phase 1 analytic balloon for INM-755 in advantageous volunteers.

CBN is additionally the API in InMed’s additional artefact candidate, INM-088, actuality advised as a abeyant analysis for ocular disease. INM-088 is in preclinical testing and avant-garde conception development with an aim to abatement intraocular burden and accommodate neuroprotection for individuals adversity from glaucoma.

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Both INM-755 and INM-088 are advised for contemporary administering at the ache site, gluttonous to abstain abeyant ancillary furnishings accompanying to systemic exposure. InMed has filed patents to assure its use of CBN and added attenuate cannabinoids to amusement these and added abeyant diseases, as able-bodied as patents directed arise our proprietary biosynthesis platform. 

About InMed: InMed Pharmaceuticals is a analytic date biopharmaceutical aggregation developing a activity of cannabinoid-based medications that ambition diseases with aerial unmet medical need.  The Aggregation is committed to carrying new ameliorative alternatives to patients that may account from cannabinoid-based medicines.  For added information, appointment www.inmedpharma.com.

About Cannabinol (“CBN”): CBN is a attenuate cannabinoid with altered physiological backdrop that may aftereffect in audible ameliorative and assurance characteristics about to the added frequently accepted cannabinoids tetrahydrocannabinol (“THC”) and cannabidiol (“CBD”).  CBN occurs artlessly in the cannabis plant, but about alone in trace quantities. InMed Pharmaceuticals is exploring the ameliorative abeyant of CBN in diseases with aerial unmet medical need, while additionally developing a proprietary biosynthesis belvedere to economically aftermath pharmaceutical-grade cannabinoids at bartering scale. 

About INM-755:  INM-755 is a proprietary, topical, cannabinol-based chrism artefact applicant advised as a contemporary analysis to amusement epidermolysis bullosa (EB) and potentially added dermatological ache indications. Preclinical abstracts authenticate that INM-755 may advice abate authentication EB symptoms, such as deepening and pain, as able-bodied potentially restore the candor of the bark in a subset of EB Simplex patients.

About Epidermolysis Bullosa (“EB”):  EB is the aggregate name of a accumulation of abiogenetic disorders of affiliation tissues affecting individuals from bearing and is characterized by brittle bark that is calmly damaged, arch to all-encompassing baking and wounding. The blisters may arise in acknowledgment to accessory injury, alike from heat, rubbing, abrading or adhering tape.  The ache has no absolute cure and all currently acclimated treatments are directed arise evidence relief.

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About INM-088:  InMed is developing INM-088 as a cannabinol (“CBN”) eye bead conception targeting abridgement of the intraocular burden associated with glaucoma as able-bodied as actuality advised to serve as a neuroprotectant to the retinal ganglion cells.

About Glaucoma:  Glaucoma is a accumulation of eye altitude characterized by abnormally aerial burden in the eye, which can accident the membranes of the retina and the arch of the optic nerve, arch to blindness. Glaucoma is the additional arch account of amaurosis accepted and can action at any age but is added accepted in earlier adults.

Cautionary Note Apropos Forward-Looking Information:This account absolution contains “forward-looking information” and “forward-looking statements” (collectively, “forward-looking information”) aural the acceptation of applicative balance laws. Advanced advice is based on management’s accepted expectations and behavior and is accountable to a cardinal of risks and uncertainties that could account absolute after-effects to alter materially from those declared in the advanced statements. Advanced advice in this account absolution includes statements about: arch the way in the analytic development of CBN to amusement animal disease; CBN accepting abeyant ameliorative advantages in specific ache models over assertive cannabinoids; exploring avant-garde biosynthetic accomplishment methods and ameliorative applications of CBN formulations to ambition diseases with aerial unmet medical need; INM-755 actuality able to amusement affection accompanying to EB and potentially added dermatological ache indications; INM-755 acceptable bark candor in a subset of EB Simplex patients; INM-088 actuality developed as an eye-drop to potentially amusement ocular ache by abbreviating intraocular burden and accouterment neuroprotection; INM-755 and INM-088 aspersing abeyant ancillary furnishings accompanying to systemic exposure; developing a proprietary biosynthesis belvedere to economically aftermath pharmaceutical-grade cannabinoids at bartering calibration as able-bodied as a activity of cannabinoid-based medications that ambition diseases with aerial unmet medical needs.

With account to the advanced advice independent in this account release, InMed has fabricated abundant assumptions regarding, amid added things: connected and appropriate absolute preclinical and analytic ability data; the acceleration of authoritative approvals; the capability of apparent protection; appeal for InMed’s products; and connected bread-and-butter and bazaar stability. While InMed considers these assumptions to be reasonable, these assumptions are inherently accountable to cogent business, economic, competitive, bazaar and amusing uncertainties and contingencies.

Additionally, there are accepted and alien accident factors which could account InMed’s absolute results, achievement or achievements to be materially altered from any approaching results, achievement or achievements bidding or adumbrated by the advanced advice independent herein. Accepted accident factors include, amid others: INM-755 may not aftermath the adapted effects; InMed may not be able to beforehand its added artefact candidates, such as INM-088, on a appropriate basis, or at all; authoritative filings may not be filed or accustomed on a appropriate basis, or at all; apparent aegis may not be acceptable to assure InMed’s bookish property; analytic trials may not advance as anticipated; bread-and-butter or bazaar altitude may worsen; InMed’s proprietary biosynthesis accomplishment action and biologic development programs may not bear the accepted akin of results; and InMed may not be able to accommodate new ameliorative alternatives that account patients via cannabinoid-based medicines. A added complete altercation of the risks and uncertainties adverse InMed is appear in InMed’s best contempo Annual Advice Form and added connected acknowledgment filed with Canadian balance authoritative authorities on SEDAR at www.sedar.com.

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All advanced advice herein is able in its absoluteness by this cautionary statement, and InMed disclaims any obligation to alter or amend any such advanced advice or to about advertise the aftereffect of any revisions to any of the advanced advice independent herein to reflect approaching results, contest or developments, except as appropriate by law.

NEITHER THE TORONTOSTOCK EXCHANGE NOR ITS REGULATIONS SERVICES PROVIDER HAVE REVIEWED OR ACCEPT RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS RELEASE.

View aboriginal agreeable to download multimedia:https://www.prnewswire.com/news-releases/inmed-first-to-advance-cannabinol-cbn-into-therapeutic-clinical-trials-300989244.html

SOURCE InMed Pharmaceuticals Inc.

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