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Business Activity Statement Form Y Xml

VANCOUVER, British Columbia–(BUSINESS WIRE)–Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical aggregation developing multifunctional biotherapeutics, today accent its key accomplishments in 2019 and adapted its accumulated priorities. Zymeworks additionally appear assorted analytic affairs advances for its beforehand candidates, ZW25 and ZW49.

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Recent ZW25 and ZW49 Affairs Advances

“Our cogent achievements in 2019 authenticate that we are active on our eyes to authorize ZW25 as the basal HER2 analysis beyond the spectrum of HER2-expressing cancers and curve of therapy,” said Ali Tehrani, Ph.D., President and CEO at Zymeworks. “As our added ameliorative candidate, ZW49, continues to beforehand in the clinic, we are aflame about its transformative abeyant for both patients with HER2-expressing cancers and for the development of approaching antibody-drug conjugate therapies. With a abstracted administration team, key hires company-wide, and a able banking position, we are accessible to bear on our analytic programs and partnering priorities for 2020.”

2019 Achievements

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ZW25 Distinct Abettor and Chemotherapy Aggregate Abstracts Presented at Assorted Medical Meetings; Abstracts Abutment Affairs for Assorted Registration-Enabling Studies

ZW49 Enters Phase 1 Analytic Testing for HER2-Expressing Cancers

Partnerships Continue to Advance; Anniversary Payments Received

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Expertise Added to Administration Aggregation

Balance Sheet Strengthened

Adapted Accumulated Priorities

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About Zymeworks Inc.

Zymeworks is a clinical-stage biopharmaceutical aggregation committed to the development of next-generation multifunctional biotherapeutics. Zymeworks’ apartment of ameliorative platforms and its absolutely chip biologic development agent accredit absolute engineering of awful differentiated artefact candidates. Zymeworks’ beforehand analytic candidate, ZW25, is a atypical Azymetric™ bispecific antibiotic currently in Phase 2 analytic development. Zymeworks’ added analytic candidate, ZW49, is a bispecific antibody-drug conjugate currently in Phase 1 analytic development and combines the different architecture and antibiotic framework of ZW25 with Zymeworks’ proprietary ZymeLink™ cytotoxic payload. Zymeworks is additionally advancing a abysmal preclinical action in oncology (including immuno-oncology agents) and added ameliorative areas. In addition, its ameliorative platforms are actuality leveraged through cardinal partnerships with nine biopharmaceutical companies. For added information, visit www.zymeworks.com.

Cautionary Note Apropos Forward Looking Statements

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This columnist absolution includes “forward-looking statements” aural the acceptation of the U.S. Private Balance Litigation Reform Act of 1995 and “forward-looking information” aural the acceptation of Canadian balance laws, or collectively, advanced statements. Advanced statements in this account absolution accommodate statements that chronicle to Zymeworks’ eyes to authorize ZW25 as the basal HER2 therapy, Phase 2 analytic balloon evaluating ZW25 in aggregate with palbociclib and analytic accord with Pfizer, strategies for the development of ZW25 and ZW49, advancing accomplishment of accumulated priorities, and accepted analytic after-effects and preclinical data, as able-bodied as the attributes and advance of Zymeworks’ accepted and projected accumulated partnerships and added advice that is not actual information. When acclimated herein, words such as “believe”, “may”, “plan”, “estimate”, “continue”, “anticipate”, “expect”, “goal”, “vision”, “potential”, and agnate expressions are advised to analyze advanced statements. In addition, any statements or advice that accredit to expectations, beliefs, plans, projections, objectives, performance, or added characterizations of approaching contest or circumstances, including any basal assumptions, are forward-looking. All advanced statements are based aloft Zymeworks’ accepted expectations and assorted assumptions, including assumptions apropos advancing advertisement of added analytic and preclinical data, the adeptness of ZW25, ZW49, and Zymeworks’ ameliorative platforms, and Zymeworks’ adeptness to access into new affiliation arrangements. Zymeworks believes there is a reasonable base for its expectations and beliefs, but they are inherently uncertain. Zymeworks may not apprehend its expectations, and its behavior may not prove correct. Actual after-effects could alter materially from those declared or adumbrated by such advanced statements as a aftereffect of assorted factors, including, after limitation, bazaar altitude and the factors declared beneath “Risk Factors” in Zymeworks’ Quarterly Report on Form 10-Q for its budgetary division concluded September 30, 2019 (a archetype of which may be acquired at www.sec.gov and www.sedar.com). Consequently, advanced statements should be admired alone as Zymeworks’ accepted plans, estimates, and beliefs. You should not abode disproportionate assurance on advanced statements. Zymeworks cannot agreement approaching results, events, levels of activity, performance, or achievements. Zymeworks does not undertake and accurately declines any obligation to update, republish, or alter any advanced statements to reflect new information, approaching events, or circumstances, or to reflect the occurrences of hasty events, except as may be appropriate by law.

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